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"Tooley, Michael H"
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Engineering GCSE Curriculum Support Pack
Used alongside the textbook Engineering GCSE, this pack offers a complete course for the new GCSE syllabuses from Edexcel and OCR, providing all the resources needed by a busy teacher or lecturer as well as a student-centred learning programme that will enable students to gain the skills, knowledge and understanding they require. The photocopiable materials in this pack include: * Background to running a GCSE Engineering course * Worksheets to support and develop work in the textbook * Assignments, practicals and design briefs * Reference material and revision sheets for use as handouts This pack builds on the success of Mike Tooley's GNVQ materials, which have helped thousands of students to gain their first engineering qualification. Mike Tooley is Vice Principal at Brooklands College, Surrey, and author of many engineering and electronics books.
eBook
مبادئ هندسة الطائرات
إنه الكتاب الأول في سلسلة محكمة من المقررات المخصصة لهندسة وإدامة الطائرات ويعد مرجعا قيما لكل من يرغب باحتراف هندسة الطائرات أو إدامتها أو أي مجال ذي صلة بالهندسة الجوية-الفضائية يوفر الكتاب : توليفة متكاملة من المعلومات الأكاديمية والعملية في مجال هندسة وإدامة الطائرات. المبادئ الأساسية والمعرفة المطلوبة لتقنيي الطائرات المخولين والمهندسين المجازين ذوي الجدارة ب JAR 66/Part-66. التكامل وسهولة التناول، مع أسئلة للاختبار الذاتي وتمرينات وأسئلة متعددة الاختيار، لتعزيز التعلم الذاتي، أو المعتمد على معلم وتسهيله. لقد تم فحص كافة ما ورد في الكتاب من مفاهيم بعناية وعمق بما يتوافق ومتطلبات وحدات المقرر العالمي JAR-66-Part-66 ووحدات (AE CGM) (Aerospace Engineering City and Guilds Modules) وعناصر EDEXCEL العالي ودرجة (FD) (Foundation Degree). وبذلك يعد المدخل المعرفي الأساسي والعالمي إلى صناعة وإدامة الطائرات وفرص العمل فيها والإطار القانوني والتشريعي لها، بالإضافة إلى تعزيز ثقافة السلامة (والأمنية) فيها.
Book
Time, Tense, and Causation
Michael Tooley presents a major new philosophical theory of the nature of time. He argues for a dynamic conception of the universe, according to which past, present, and future are not merely subjective features of experience: past and present are real, while the future is not. The key to understanding the nature of time is to understand the relation between time and causation. Time, Tense, and Causation is a landmark treatment of one of the oldest and mostfascinating of intellectual problems; it provides sophisticated and stimulating discussions of a wide range of metaphysical issues.'Tooley's provocative book makes an extremely valuable contribution to the literature on the philosophy of time and is mandatory reading for anyone working in the area.' L. Nathan Oaklander, Mind.
eBook
Schizophrenia risk from complex variation of complement component 4
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C4A. Human C4 protein localized to neuronal synapses, dendrites, axons, and cell bodies. In mice, C4 mediated synapse elimination during postnatal development. These results implicate excessive complement activity in the development of schizophrenia and may help explain the reduced numbers of synapses in the brains of individuals with schizophrenia.
Journal Article
An analysis-ready and quality controlled resource for pediatric brain white-matter research
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated the HBN dMRI data (N = 2747) into the Brain Imaging Data Structure and preprocessed it according to best-practices, including denoising and correcting for motion effects, susceptibility-related distortions, and eddy currents. Preprocessed, analysis-ready data was made openly available. Data quality plays a key role in the analysis of dMRI. To optimize QC and scale it to this large dataset, we trained a neural network through the combination of a small data subset scored by experts and a larger set scored by community scientists. The network performs QC highly concordant with that of experts on a held out set (ROC-AUC = 0.947). A further analysis of the neural network demonstrates that it relies on image features with relevance to QC. Altogether, this work both delivers resources to advance transdiagnostic research in brain connectivity and pediatric mental health, and establishes a novel paradigm for automated QC of large datasets.
Journal Article
Retinopathy of prematurity in English neonatal units: a national population-based analysis using NHS operational data
Objectives To report on retinopathy of prematurity (ROP) screening compliance against a national guideline, factors associated with non-compliance and effect on ROP treatment. Design National cohort study using operational NHS data from the National Neonatal Research Database (NNRD) for the period 2009–2011. Setting 161 (94%) neonatal units in England. Population Infants born below 32 weeks’ gestation and/or with a birth weight below 1501 g. Main outcome measures ROP screening status (‘on-time’, ‘early’, ‘late’, ‘unknown’) and associated infant and neonatal unit characteristics, ROP treatment. Results The proportion of infants screened on-time increased over the study period (p<0.001). Of 19 821 eligible infants, 7602 (38.4%) were recorded to have received ROP screening in accordance with the national guideline; 7474 (37.8%) received screening outside the recommended time period; data were missing for 4745 (16.7%) infants. For 16 411 infants in neonatal care during the recommended screening period, late screening was significantly associated with lower gestational age (relative risk ratio (RRR) (95% credible interval) for late versus on-time screening 0.83 (0.80 to 0.86) for each increased week of gestation) and care in a neonatal unit providing less than 500 days of intensive care per annum (2.48 (0.99 to 4.99)). Infants screened late were almost 40% more likely to receive ROP treatment (OR (95% CI) 1.36 (1.05 to 1.76)). Conclusions Understanding organisational differences between neonatal units may help improve ROP screening. Patient-level electronic NHS clinical data offer opportunity for future rapid, low cost, population-based evaluations but require improved data entry.
Journal Article